Trypanosoma brucei Assembly and Gene Annotation

About the Trypanosoma brucei genome

Trypanosoma brucei, an extracellular eukaryotic parasite causes human African trypanosomiasis, or sleeping sickness in human and nagana in animals in Africa. They are transmitted by tsetse fly.

Assembly

T. brucei nuclear genome and the mitochondrial (kinetoplast) together have an estimated size of 35Mb/haploid genome. The T. brucei genome contains a ~0.5Mb segmental duplication affecting chromosomes 4 and 8, which is responsible for some 75 gene duplicates unique to this species. The assembly is also available from the EMBL/Genbank/DDBJ databases under the accession GCA_000209005.1.

Annotation

Annotation of the T. brucei brucei genome has been derived from annotation submitted to the EMBL/Genbank/DDBJ databases; and enhanced by importing data from additional sources, principally UniProtKB and GOA.

References

1. The genome of the African trypanosome Trypanosoma brucei.
   Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B et al. 2005. Science. 309:416-422.

Picture credit: Image courtesy of Dr. Sophie May, Prof. Laurence Tetley and Dr. Tansy Hammarton from Wellcome Trust Centre For Molecular Parasitology

More information

General information about this species can be found in Wikipedia.