Plasmodium falciparum - GCA_000002765.3 Assembly and Gene Annotation

About Plasmodium falciparum

Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria. P. falciparum is therefore regarded as the deadliest parasite in humans. It is also associated with the development of blood cancer and is classified as a Group 2A (probable) carcinogen.

Picture credit: Public domain via Wikimedia Commons (Image source) Taxonomy ID 36329

(Text from Wikipedia.)

More information General information about this species can be found in Wikipedia

Assembly

The Plasmodium falciparum genome has a total size of 23Mb, organized in 14 chromosomes and is available from the ENA/Genbank databases under the accession GCA_000002765.3.

Due to its size and the high AT content, a chromosome-based approach was chosen for the sequencing strategy. The chromosomes from P. falciparum 3D7 were distributed among the sequencing centers that make up the P. falciparum Genome Sequencing Consortium](http://www.sanger.ac.uk/Projects/P_falciparum/who&what.shtml), established in 1996. The sequencing centers involved in this research program are The Sanger Institute, The Institute for Genomic Research(TIGR), in collaboration with the US Naval Medical Research Center, and the Stanford Genome Technology Center](http://med.stanford.edu/sgtc/research/malaria.html) at Stanford University.

Annotation

The annotation has been imported from VEuPathDB.

References

1. Genome sequence of the human malaria parasite Plasmodium falciparum.
   Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S et al. 2002. Nature. 419:498-511.
2. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.
   Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S et al. 2002. Nature. 419:527-531.
3. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.
   Gardner MJ, Tettelin H, Carucci DJ, Cummings LM, Aravind L, Koonin EV, Shallom S, Mason T, Yu K, Fujii C et al. 1998. Science. 282:1126-1132.
4. Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum.
   Wilson RJ, Denny PW, Preiser PR, Rangachari K, Roberts K, Roy A, Whyte A, Strath M, Moore DJ, Moore PW et al. 1996. J. Mol. Biol.. 261:155-172.
5. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
   Bowman S, Lawson D, Basham D, Brown D, Chillingworth T, Churcher CM, Craig A, Davies RM, Devlin K, Feltwell T et al. 1999. Nature. 400:532-538.