About Trypanosoma cruzi (GCA_000188675)
Trypanosoma cruzi is a species of parasitic euglenoid protozoan. Amongst the protozoa, the trypanosomes characteristically bore tissue in another organism and feed on blood, and lymph. This behaviour causes disease or the likelihood of disease that varies with the organism: for example, trypanosomiasis in humans (Chagas disease in South America and sleeping sickness in Africa), dourine and surra in horses, and a brucellosis-like disease in cattle. Parasites need a host body and the haematophagous insect triatomine (descriptions "assassin bug", "cone-nose bug", and "kissing bug") is the major vector in accord with a mechanism of infection. The triatomine likes the nests of vertebrate animals for shelter, where it bites and sucks blood for food. Individual triatomines infected with protozoa from other contact with animals transmit trypanosomes when the triatomine deposits its faeces on the host's skin surface and then bites. Penetration of the infected faeces is further facilitated by the scratching of the bite area by the human or animal host.
Trypanosomiasis in humans progresses with the development of the trypanosome into a trypomastigote in the blood and into an amastigote in tissues. The acute form of trypanosomiasis is usually unnoticed, although it may manifest itself as a localized swelling at the site of entry. The chronic form may develop 10 to 20 years after infection and affect internal organs (e.g., the heart, the oesophagus, the colon, and the peripheral nervous system). Affected people may die from heart failure.
Acute cases are treated with nifurtimox and benznidazole, but no effective therapy for chronic cases is currently known.
Taxonomy ID 5693
Data source European Nucleotide Archive
This species currently has no variation database. However you can process your own variants using the Variant Effect Predictor: